There is no specific treatment for WNV infection. In cases with milder symptoms, people experience fever and aches that subside on their own. Over-the-counter pain relievers can be used to help reduce fever and relieve associated symptoms. In more severe cases, people may need to go to the hospital where they can receive supportive care, such as intravenous fluids, pain management, and nursing care.
There is no vaccine available to prevent people from becoming infected with WNV.